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Window Period for Oxidative Stress Attenuating Intervention

(WPOS Theory)

Sino-US Pficker Pharmaceuticals Co., Ltd, #85 Nanli Road, Huaibei City, Anhui Province, China

*Corresponding Author:

Zuolin Zhu

Sino-US Pficker Pharmaceuticals Co., Ltd

#85 Nanli Road

Huaibei City

Anhui Province, China

Email: zuolinzhu@pficker.com.cn or zuolinzhu@yahoo.com

Abstract

Clinical trials of antioxidant intervention involving hundreds of human participants have shown almost entirely no positive results or even adverse ones. Other in vitro and animal tests have presented a preponderance of evidence that antioxidant intervention protects cell from damage and is effective in disease prevention. In this review we compared the results from in vitro tests and animal tests with those derived from human clinical trials and found out that there are important differences between them. For in vitro and animal tests, the cells or animals under study either have abnormal levels of oxidative stress before antioxidant intervention or their oxidative stress levels are increased to abnormal levels immediately afterwards. Clinical trials based on data from the general human population gave no benefits or even adverse results, although benefits were observed for clinical trials involving participants with abnormal levels of oxidative stress, such as those with diabetes. I propose a novel theory, "Window Period for Oxidative Stress Attenuating Intervention" (WPOS), that can give a reasonable explanation for the confusing results encountered in the research of oxidative stress up to now. It suggests that antioxidant intervention will play a key role in preventing but not curing disease.

Keywords:  Antioxidant intervention; oxidative stress; disease prevention; diabetes.

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