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Metallo Protoporphyrin Functionalized Microelectrodes for Electrocatalytic Sensing of Nitric Oxide

¹Nanobioengineering/Bioelectronics Lab, Department of Biomedical Engineering, Florida International University, Miami, Florida, USA

² World Precision Instruments, Inc, 175 Sarasota Center Boulevard, Sarasota, Florida, USA
*Corresponding author

Dr. Chenzhong Li
Nanobioengineering/Bioelectronics Lab.
Department of Biomedical Engineering 

Florida International University
10555 W. Flager St. Miami, Florida 33174
Tel: 305 348 0120

Email: licz@fiu.edu

Abstract

Nitric oxide (NO) has been considered as an important bio-regulatory molecule in the physiological process.  All the existing methods often employed for NO measurement are mainly indirect and not suitable for in vivo conditions.  In this paper, we report a systematic study of electrocatalytic NO reduction by comparing the redox properties of NO at carbon microelectrodes functionalized by Fe, Mn and Co protoporphyrins.  The mechanisms of electrocatalytic reduction of NO by different metalloporphyrins have been proposed and compared. In addition, by varying the metallic cores of the metalloporphyrins, NO exhibits voltammograms in which the cathodic peak current occur at different potential.  A comparative study on the electrochemical behavior of each of these metalloporphyrin (as a result of varying the metallic core) has been performed and a possible mechanism for the observed behavior is proposed.  The results confirmed the potential applicability of using metalloporphyrins modified electrodes for voltammetric NO detection.  

Keywords:  Nitric oxide; biosensor; electrocatalytic reduction; microelectrode; protoporphyrin.

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