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Characterization of DNA-Nanopore Interactions by Molecular Dynamics

¹Biomedical Engineering,

²Mechanical and Aerospace Engineering,

³Nanotechnology Research and Teaching Facility,

⁴Department of Electrical Engineering, University of Texas at Arlington, Arlington, TX, 76019

*Corresponding Author:

Yaling Liu

Department of Mechanical and Aerospace Engineering

University of Texas at Arlington

Arlington, TX, 76019

Phone: 817-272-1256

Email: yaling.liu@uta.edu

Abstract

A major challenge in using solid-state nanopores for DNA detection and sequencing is the molecular selectivity and sensitivity resolution through proper control of DNA-nanopore interface. This paper explores the interaction mechanisms between DNA and nanopores through molecular dynamics simulations.   The DNA translocation dynamics through nanopores of various diameters and under various applied bias-voltages are characterized. Such property-function relationship can be used for the optimal designs of the lab-on-chip DNA diagnostic devices.   

Keywords:  Nanopore; DNA; Molecular Dynamics; Molecular Interaction.

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