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| Am. J. Biomed. Sci. 2010, 2(2), 164-177; doi: 10.5099/aj100200164 |
Study of Antimutagenic Potential of
Phytoconstituents Isolated from Terminalia
arjuna in the Salmonella/Microsome Assay |
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Satwinderjeet Kaura*, Subodh Kumarb, Prabhjit
Kaura and Madhu Chandela |
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a Department of Botanical & Environmental
Sciences, |
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b Department of Chemistry, |
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Guru Nanak Dev University, Amritsar-143005, Punjab,
India. |
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*Corresponding Author: |
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Dr. Satwinderjeet Kaur (Reader) |
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Department
of Botanical and Environmental Sciences, |
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Guru
Nanak Dev University, |
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Amritsar-143005,
(Punjab) India |
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Email: sjkaur@rediffmail.com;
sjkaur2001@yahoo.co.in |
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Abstract Two fractions ET-1 and TW isolated from Terminalia arjuna were evaluated for their antimutagenic potential against 4-nitro-o-phenylenediamine (NPD) in TA98, sodium azide in TA100 and 2-aminofluorene, in both TA98 and TA100 tester strains of Salmonella typhimurium using bacterial reverse mutation assay. Both the fractions inhibited the mutagenicity of 2AF significantly in both the strains. ET-1 fraction inhibited the mutagenicity of base pair substitution mutagen sodium azide by 77.41% at 1x103 μg/0.1ml. It did not inhibit the mutagenicity of NPD. TW fraction showed insignificant inhibitory activity against the mutagenicity of NPD and sodium azide in TA100 and TA98 tester strains respectively. 1H-NMR, 13C-NMR and IR-spectroscopic data of the fractions revealed ET-1 fraction as a diglycoside of triterpene and TW fraction as tannin in nature. Keywords: Terminalia arjuna; Antimutagenesis; Ames assay; Salmonella typhimurium. Download the full article (PDF)
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