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Studies on the Development of a Non-genetic Obese Type 2 Diabetic Rat Model: Amelioration by (+)-Catechin Hydrate

¹ Department of Biochemistry, Panjab University, Chandigarh-160014, India.

² Department of Biophysics, Panjab University, Chandigarh-160014, India.

*Corresponding author

Dr. Devi Dayal Bansal

Department of Biochemistry

Basic Medical Sciences Block

Panjab University, Chandigarh-160014.

INDIA

Telephone: (O) +91-172-2534131; (M): +919814911579

Email: bansal_devi@yahoo.com

Abstract

This study was planned to investigate the effect of pure catechin, a green tea flavonoid on the levels of fasting plasma glucose, plasma insulin, plasma and tissue lipids in high fat high sucrose diet fed rats for a period of 12 weeks. The results indicate that feeding the rats with high fat and high sucrose diet resulted into the development of an obese type 2 diabetic rat model and (+)-catechin hydrate to some extent prevented the weight gain, rise in blood glucose, cholesterol and Triglyceride levels. Insulin levels were also high in high fat high sucrose fed rats as compared to rats fed high fat, high sucrose and administered (+)-catechin hydrate. Catechin also prevented the weight gain in control group thereby limiting its role only in obesity. Catechin supplementation in rats fed high fat and high sucrose diet was also found to prevent increase in cholesterol, triglycerides and glycolipid levels in liver and cholesterol and glycolipid levels in heart. In conclusion high fat and high sucrose diet is useful in the development of an obese type 2 diabetic rat model and catechin to some extent is beneficial.

Keywords:  (+)-catechin hydrate; liver; heart; triglyceride; cholesterol.

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