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Controlled Release of Doxofylline from Biopolymer Based Hydrogels

^a*Polymer Research Unit, Department of Chemistry, Utkal University, Vani Vihar, Bhubaneswar 751004, India

^b P.G. Department of Pharmaceutics, Sri Jayadev College of Pharmaceutical Sciences, Bhubaneswar 752101, India

*Corresponding author

Polymer Research Unit,

Department of Chemistry,

Utkal University, Vani Vihar,

Bhubaneswar, 751004, India.

Tel.: (91-674) 2582734

Fax: (91-674) 2582734.

E mail: gils.ps@gmail.com

Abstract

In order to modify the xanthan gum (XG) polysaccharide and to develop the hydrogels meant for the drug delivery, we have prepared XG-g-poly [HEMA-co-AA] superporous hydrogel (SPH) through chemical cross-linking by graft copolymerization of 2-hydroxyethyl methacrylate (HEMA) and acrylic acid (AA) on to XG via redox initiator system of ammonium persulfate (APS) and N, N, N', N' -tetramethylethylenediamine (TMED), in the presence of N, N' -methylenebisacrylamide (MBA) crosslinking agent, sodium bicarbonate foaming agent, a triblock copolymer of polyoxyethylene/ polyoxypropylene/ polyoxyethylene as a foam stabilizer. Characterization of SPH was done by FT-IR, TGA, SEM, HPLC and GCMS. The prepared SPH were successfully loaded with Doxofylline (DF) drug and formulation H₁₀ showed higher % drug content (98±2.3) and % drug entrapment efficiency (83±2.0). From the in Vitro drug release study in pH progressive media, formulation H₁₀ showed comparatively higher release extending upto 24h.The mechanism of DF release from the SPH matrix was found to be of diffusion type.

Keywords:  Hydrogel, Polysaccharide, Monomer residuals, Doxofylline, Controlled drug delivery.

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