Antipyretic, Antidiabetic, Thrombolytic and CNS Depressant Potential of Ethanol Extract of Crotalaria Verrucosa L. Leaves

Avejet Roy¹, A. K. M. Radowan Ahmad², Md. Nurul Islam¹

¹Department of Pharmaceutical Sciences, North South University, Bangladesh.

²Department of Pharmacy, East West University, Bangladesh.

^*Corresponding Author

Kashfia Nawrin

Department of Pharmaceutical Sciences

North South University

Bangladesh

Cell no. +880 1911749930.

Email: kashfianawrin@hotmail.com

Abstract

Hyperthermia, hyperglycemia, depression are the most common physiological disorders found in third world countries where people are not well aware of their health condition as well as about their health practice. People in rural and tribal areas depend on the traditional system of medicine where allopathic medicines are not the first choice because of ethnicity and belief. The plant Crotalaria verrucosa is believed as one of the cures in traditional system of medicine for many ailments. The present study was performed to evaluate the antipyretic, antidiabetic, thrombolytic and depressive potential of the leaf extract of this plant. Yeast induced pyrexia, alloxan induced type II hyperglycemia, HRBC clot denaturation, Hole cross and Open field tests were performed to investigate these activities at moderate to high doses (100, 250 and 500 mg/kg). Results of the study suggests that the extract possess strong antipyretic, antidiabetic and CNS depressant activity in higher doses (250 and 500 mg/kg) but lack to exhibit clear thrombolytic potential.

Keywords: pyrexia, diabetic, clot lysis, locomotor activity, C. verrucosa.

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